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Deplin® Facts

How Does Deplin® Work?
Deplin® works through a natural process in the brain to regulate all three monoamine neurotransmitters associated with mood by providing the increased dietary requirements for folate. L-methylfolate is needed by depressed patients with suboptimal folate to regulate the synthesis of monoamines (serotonin, norepinephrine and dopamine) and known as a trimonoamine modulator (TMM). By managing trimonoamine neurotransmitter synthesis, L-methylfolate, when taken with antidepressants, improves benefits.1, 2

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Deplin® vs. Folic Acid
Folic acid is a man-made product that needs to broken down by the body through a lengthy 4-step process. Folate that comes from your diet (e.g green vegetables) must undergo a 3-step transformation.

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What To Expect
Are there side effects with Deplin®? How do I take it? What are the benefits?

These questions and more are answered here »


Deplin® (7.5mg or 15mg L-methylfolate) is a prescription medical food for the dietary management of suboptimal folate levels in depressed patients.

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