How Does Deplin® Work?

Deplin® is a trimonoamine modulator containing 7.5 mg of L-methylfolate, the only active form of folate that can cross the blood brain barrier.

L-methylfolate crosses the blood brain barrier and aids in the synthesis of new neurotransmitters (brain chemicals) associated with mood.

Deplin® works through a natural process in the brain to regulate all three monoamine neurotransmitters associated with mood by providing the increased dietary requirements for folate. L-methylfolate is needed by depressed patients with suboptimal folate to regulate the synthesis of monoamines (serotonin, norepinephrine and dopamine) and known as a trimonoamine modulator (TMM). By managing trimonoamine neurotransmitter synthesis, L-methylfolate, when taken with antidepressants, improves benefits.

View Deplin's mechanism of action, as referenced in Stephen Stahl's "Essentials of Psychopharmacology" 3rd edition.


Deplin® vs. Folic Acid »


Deplin® (7.5mg or 15mg L-methylfolate) is a prescription medical food for the dietary management of suboptimal folate levels in depressed patients.

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