What To Expect
Are there side effects with Deplin?
L-methylfolate was well tolerated in both short-term and long-term trials. Side effects did not differ from a sugar pill (placebo). Deplin® has not been associated with weight gain, sexual dysfunction or nausea.
How do I take Deplin®?
For best results, you should take Deplin® exactly as prescribed by your doctor. For most people, Deplin is prescribed once a day, every day, with or without food. You should also fill your prescriptions ahead of time to avoid missing a dose.
When will I feel an effect and what can I expect?
You may begin to feel better after taking Deplin for 1 to 2 weeks, but the full effect may take 4 to 6 weeks. You may feel an improvement in one or more of the following areas:14
- Drive
- Initiative
- Alertness
- Concentration
- Mood
- Sociability
How long do I have to take it?
For some, depression can be an ongoing condition that may require long-term treatment. Your healthcare provider will track your progress and work with you to determine the right length of treatment. Do not stop taking Deplin without talking to your doctor.
Will Deplin® affect other medications I might be taking?
Deplin® does not require dosing adjustments when taken together with most medications. Deplin® may lower the levels of the following anticonvulsants (mood stabilizers): carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid. If you are taking one of these medications, let your doctor know.
What other safety information should be considered?
Deplin® may mask the diagnosis of pernicious anemia caused by a lack of B12. Deplin® will not cause pernicious anemia, but if you believe you may be anemic, consult with your doctor immediately.
When would Deplin® not be right for me?
If you have a known hypersensitivity to folate or folic acid.
Deplin® is the first medical food product indicated for the distinct nutritional requirements of persons with low plasma and/or low red blood cell folate with particular emphasis for those individuals who have a major depressive disorder that has not fully responded or may not fully respond to antidepressant therapy.
