What To Expect
Deplin® works through a natural process in the brain to regulate all three monoamine neurotransmitters associated with mood by providing the increased dietary requirements for folate. L-methylfolate is needed by depressed patients with suboptimal folate to regulate the synthesis of monoamines (serotonin, norepinephrine and dopamine) and known as a trimonoamine modulator (TMM). By managing trimonoamine neurotransmitter synthesis, L-methylfolate, when taken with antidepressants, improves benefits.
Are there side effects with Deplin®?
L-methylfolate was well tolerated in both short-term and long-term trials. Side effects did not differ from a sugar pill (placebo).15-18 Deplin® has not been associated with weight gain, sexual dysfunction, nausea, or akathisia.15-21
How do I take Deplin®?
For best results, you should take Deplin® exactly as prescribed by your doctor. For most people, Deplin® is prescribed once a day, every day, with or without food. You should also fill your prescriptions ahead of time to avoid missing a dose.
What are the benefits of managing sub-optimal folate levels in the brain?
You may begin to notice a difference after taking Deplin® for 1 to 2 weeks, but the full effect may take 4 to 6 weeks. You may feel improvement in one or more of the following: 18, 22, 23
- Motivation
- Initiative
- Alertness
- Concentration
- Mood
- Sociability
How long do I have to take it?
For some, depression can be an ongoing condition that may require long-term treatment. Your healthcare provider will track your progress and work with you to determine the right length for you. Do not stop taking Deplin® without talking to your doctor.
Will Deplin® affect medications I might be taking?
Deplin® does not require dosing adjustments when taken together with most medications. Deplin® may lower the levels of the following anticonvulsants (mood stabilizers): carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid. If you are taking one of these medications, let your doctor know.
What other safety information should be considered?
Folic acid has been associated with masking pernicious anemia. Deplin® has not been associated with masking pernicious anemia. If you believe you may be anemic, consult with your doctor immediately.
When would Deplin® not be right for me?
If you have a known hypersensitivity to folate or folic acid.
Deplin® (7.5mg or 15mg L-methylfolate) is a prescription medical food for the dietary management of suboptimal folate levels in depressed patients.
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