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Information for Healthcare Professionals

Welcome to the Deplin® Healthcare Professional site. Get information about Deplin® for your patients.

View a L-methylfolate clinical presentation by Dr. John Zajecka
Evidence for a Trimonoamine Modulator as an Antidepressant Augmentation Agent



View Deplin's mechanism of action, as referenced in Stephen Stahl's "Essentials of Psychopharmacology" 3rd edition.

Mechanism of Action
Deplin® is a Trimonoamine Modulator (TMM).


Deplin® (L-methylfolate) is an orally administered medical food for use only under medical supervision for the dietary management of suboptimal folate levels in depressed patients.

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