Deplin^® Mechanism of Action

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By providing increased requirements of brain L-methylfolate, Deplin^® increases the synthesis of serontonin, norepinephrine and dopamine. When taken daily with your antidepressant, it results in a boost in the benefits of antidepressants.^1,2,24

• L-methylfolate is needed by depressed patients with suboptimal folate to regulate the synthesis of monoamines (serotonin, norepinephrine and dopamine) and known as a trimonoamine modulator (TMM).^1,2
• By managing trimonoamine neurotransmitter synthesis, L-methylfolate, when taken with antidepressants, improves benefits.^1,2
• Deplin^® 7.5mg (L-methylfolate) is well tolerated and has a low potential for drug interactions.^23,25

Deplin^® (L-methylfolate) is an orally administered medical food for use only under medical supervision for the dietary management of suboptimal folate levels in depressed patients.

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