Deplin® Mechanism of Action

Mechanism of Action
* Adapted with permission: Bottiglieri T, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2005; 1103-1112

Triple Action Monoamine Synthesis *

Through the one-carbon metabolism process, L-methylfolate is needed to cross the blood brain barrier and support the synthesis of monoamine neurotransmitters.

Triple action of Monoamine Synthesis

Deplin® is the first medical food product indicated for the distinct nutritional requirements of persons with low plasma and/or low red blood cell folate with particular emphasis for those individuals who have a major depressive disorder that has not fully responded or may not fully respond to antidepressant therapy.