Well tolerated in both acute and chronic therapy.
Suicide/Overdose
Precautions
Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations). L-methylfolate may be less likely than folic acid to mask vitamin B12 deficiency.38,39 Folate therapy alone is inadequate for the treatment of a B12 deficiency.
Folic acid, when administered in daily doses above 800 mg, may increase the amount of unmetabolized folic acid1, which has been linked to accelerated growth of existing neoplasms in the colon. L-methylfolate may be less likely than folic acid to accelerate the growth of existing neoplasms.40,41,42
Drug Interactions
| Drugs | Folate plasma level with adjuvant drugs | Drug plasma level with adjuvant high dose folate |
|---|---|---|
| Anticonvulsants– first generation: carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate | ||
| Other Anticonvulsants; lamotrigine | – | |
| Methotrexate | – | |
| Alcohol (excess amounts) | – | |
| Sulfasalazine | – | |
| Cholestyramine | – | |
| Colchicine | – | |
| Colestipol | – | |
| Isltretinoin | – | |
| L-Dopa | – | |
| Methylprednisone | – | |
| NSAIDs (high dose): ibuprofen, naproxen, indomethacin, sulindac | – | |
| Oral Contraceptives | – | |
| Pancreatic enzymes: pancrelipase, pancratin | – | |
| Pentamidine | – | |
| Pyrimethamine | ||
| Smoking | – | |
| Triamterene | – | |
| Trimethoprim | – |
Deplin® (L-methylfolate) is an orally administered medical food for use only under medical supervision for the dietary management of suboptimal folate levels in depressed patients.
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