Low Folate Levels and Depression

You may be at risk for low folate levels.¹⁰

If you...

• have a specific genetic factor that impairs folate metabolism
  7 out of 10 people with depression may have a specific genetic factor that limits their ability to convert folic acid or folate from the diet to L-methylfolate.¹¹ This is important because L-methylfolate is the only form of folate used by the brain to correct a neurotransmitter imbalance linked to depression.
  
  
• suffer from some chronic diseases
  Diabetes, hypothyroidism, atrophic gastritis, Crohn's, colitis, malignancies , anorexia
• take certain drugs
  

  Drug	Use
  Oral contraceptives	birth control medications
  Antiepileptic drugs	bipolar disorder, anti-seizure
  Lithium	bipolar disorder, depression
  Metformin	diabetes
  Methotrexate, sulphasalazine	arthritis, cancer
  L-dopa	Parkinson's
  Niacin, fenofibrates	high cholesterol
  Isotretinion	acne

• have a certain lifestyle
  Smoking, excess alcohol, dietary folate deficiency
  (poor nutrition, eating disorder, chronic dieting)
• are pregnant

Deplin^® Facts »

Deplin^® (L-methylfolate) is an orally administered medical food for use only under medical supervision for the dietary management of suboptimal folate levels in depressed patients.

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