Partial Response
How Common are Unresolved Symptoms With Antidepressant Treatment?
More than two thirds of depressed patients symptoms are still clinically depressed (fail to achieve remission) after the first antidepressant treatment.4
Brain with folate deficiency
People suffering from depression who do not achieve complete remission of symptoms are more likely to relapse and have a poorer long-term prognosis5,6.
Why do some people experience an inadequate response to their antidepressant?
There are several reasons why an antidepressant may lead to a partial response or non-response.
One theory is that the brain is not developing enough neurotransmitters due to insufficient folate in the brain.8 Some people might not have enough of one or more neurotransmitters for an antidepressant to work effectively.
Therefore, impairment in the development and/or release of neurotransmitters can lead to an inadequate response from an antidepressant.
