How Deplin® Works


Some Reasons Why Patients May Have Low L-methylfolate Include:

Certain medications may interfere with folate:

  • Anticonvulsant medications used to control seizures and other conditions such as lamotrigine (Lamictal®), valproate/divalproex sodium(Depakote®), and carbamazepine (Carbatrol®, Epitol®,Tegretol®)
  • Methotrexate (Rheumatrex®, Texall®) which is commonly used for psoriasis and rheumatoid arthritis
  • Sulphasalazine (Azulfidine®) for inflammatory bowel disease and rheumatoid arthritis
  • Oral contraceptives (birth control pills)
  • Metformin (Fortamet®, Glucophage®, Glumetza®) is used to treat type 2 diabetes
  • Fluoxetine (Prozac®, Sarafem®) is an antidepressant that works as a serotonin reuptake inhibitor (SSRI)
  • Niacin (Niaspan®, Slo-Niacin®) and fenofibrates (Tricor®, Trilipix®) are commonly used to lower cholesterol
  • Warfarin (Coumadin®) is an anticoagulant that prevents blood clots due to irregular heartbeat, prosthetic heart values and heart attack.
  • Isotetrinoin (Accutane®, Amnesteem®, Claravis®, Sotret®) a retinoid medication for severe acne


Some diseases have been associated with low folate:

  • Diabetes
  • Atrophic gastritis
  • Crohn’s disease
  • Colitis
  • Renal failure
  • Hypothyrodism


Certain lifestyles may lead to lower L-methylfolate

  • Excessive use of alcohol
  • Smoking
  • Poor nutrition



  • L-methylfolate in the brain decreases with age



  • Up to 70% of patients with depression have a genetic mistake, called the MTHFR polymorphism. It is an enzyme defect that compromises the body’s ability to break down folate (from the diet or from synthetic folic acid found in vitamin supplements) into the L-methylfolate the brain needs to make neurotransmitters.



Your questions answered:

How does Deplin® work?

Deplin® is a medical food that is used under the supervision of a healthcare professional.