Taking Deplin®

Deplin® should be taken exactly as directed by a healthcare professional.

Deplin® is available as a medical food in 7.5 and 15, which is taken once daily. Deplin® can be taken with or without food. For best results, Deplin® should be taken at the same time every day. Always be sure to refill your prescription ahead of time to avoid missing a dose.

It is important not to change how Deplin® is taken or stop taking Deplin® without first talking to a doctor. There is no need to slowly reduce the dose of Deplin® to avoid side effects. Anyone thinking of stopping Deplin® should talk to their doctor first before they do so.


Deplin® (L-methylfolate) is a medical food used under medical supervision and is dispensed by prescription.

L-methylfolate is the active form (the working part) of the vitamin, folate, that is naturally used by the brain. The L-methylfolate in Deplin® has been designated as G.R.A.S. (Generally Recognized as Safe) under the conditions of its intended use. There have been no recorded incidences of overdose with L-methylfolate. Because L-methylfolate is a water soluble vitamin, the body will eliminate unneeded amounts in the urine.

Your questions answered:

How should I take Deplin®?

You should take your Deplin® exactly as prescribed by your doctor and not stop taking Deplin® until your doctor advises you to do so. Most people should take one 7.5 or 15 Deplin® once daily, with or without food. 15 is the target dose for most patients but a 7.5 dose is available for dose flexibility.

Is Deplin® safe? Can it cause side effects?

The L-methylfolate found in Deplin® is Generally Recognized as a Safe (G.R.A.S.). L-methylfolate found in Deplin® is a form of folate that is naturally used in the body.