DEPLIN® Can Make a Difference When Added to an Antidepressant
Add DEPLIN® capsules for patients who are not fully responding to their antidepressant therapy
DEPLIN® provides the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively.1-4
DEPLIN® is different from OTC folic acid*
Unlike DEPLIN®, over-the-counter (OTC) folic acid needs to be converted to its active form before it can be used in the brain, a process that may be compromised in many patients with depression.1,3-6
OTC folic acid requires multiple steps of biochemical conversion to be bioavailable1,4,7
Copyright ©2008 Stephen M. Stahl. Reproduced with permission of Cambridge University Press.5
DHFR, dihydrofolate reductase; DHF, dihydrofolate; THF, tetrahydrofolate; MTHFD, 5,10-methylenetetrahydrofolate dehydrogenase; MTHFR, methylenetetrahydrofolate reductase.
The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier.
References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Levitt M, Nixon PF, Pincus JH, Bertino JR. J Clin Invest. 1971;50(6):1301-1308. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Kelly CB, McDonnell AP, Johnston TG, et al. J Psychopharmacol. 2004;18(4):567-571. 6. Gilbody S, Lewis S, Lightfoot T. Am J Epidemiol. 2007;165(1):1-13. 7. Krajinovic M. Pharmacogenomics. 2008;9(7):829-832.