Deplin® Adds Active Folate that Crosses the Blood-Brain Barrier to Work in the Brain

The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier and is thought to help enhance production of the neurotransmitters required by many patients to help achieve and maintain the benefits of antidepressants.1-6

L-methylfolate is the biologically active form of folate and is involved in neurotransmitter synthesis. L-methylfolate modulates the synthesis of monoamines.


  • L-methylfolate is the biologically active form of folate and is involved in neurotransmitter synthesis. L-methylfolate modulates the synthesis of monoamines1,2,4
    • It assists in the formation of the enzyme co-factor BH4, also known as tetrahydrobiopterin
    • BH4 activates the rate-limiting enzymes tryptophan hydroxylase and tyrosine hydroxylase for monoamine synthesis
      • Activation of tryptophan hydroxylase initiates a cascade that leads to the synthesis of serotonin, and
      • Activation of tyrosine hydroxylase initiates a cascade that leads to the synthesis of dopamine and norepinephrine
  • The addition of L-methylfolate may regulate monoamine synthesis and help to manage depression by augmenting the therapeutic benefits of antidepressants4
Discover the role of folate in depression
Discover the role of DEPLIN® on neurotransmitters in depression

 

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References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Spector R, Lorenzo AV. Am J Physiol. 1975;229(3):777-782. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Papakostas GI, Shelton RC, Zajecka JM, et al. Am J Psychiatry. 2012;169(12):1267-1274. 6. DEPLIN [package insert]. Covington, LA: Alfasigma USA, Inc.; 2017.

DEPLIN® is a medical food for use only under medical supervision for the clinical dietary management of depression and schizophrenia and is specially formulated to meet the distinctive nutritional requirement for this condition.

Manufactured and Distributed by:
Alfasigma USA, Inc.
Shreveport, LA 71104
© 2023 Alfasigma USA, Inc.


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