Active Folate Crosses the Blood-Brain Barrier to Work in the Brain
The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier and is thought to help enhance production of the neurotransmitters required by many patients to help achieve and maintain the benefits of antidepressants.1-6
- L-methylfolate is the biologically active form of folate and is involved in neurotransmitter synthesis. L-methylfolate modulates the synthesis of monoamines1,2,4
- It assists in the formation of the enzyme co-factor BH4, also known as tetrahydrobiopterin
- BH4 activates the rate-limiting enzymes tryptophan hydroxylase and tyrosine hydroxylase for monoamine synthesis
- Activation of tryptophan hydroxylase initiates a cascade that leads to the synthesis of serotonin, and
- Activation of tyrosine hydroxylase initiates a cascade that leads to the synthesis of dopamine and norepinephrine
- The addition of L-methylfolate may boost monoamine synthesis and help to manage depression by augmenting the therapeutic benefits of antidepressants4
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References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Spector R, Lorenzo AV. Am J Physiol. 1975;229(3):777-782. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Papakostas GI, Shelton RC, Zajecka JM, et al. Am J Psychiatry. 2012;169(12):1267-1274. 6. DEPLIN [package insert]. Covington, LA: Alfasigma USA, Inc.; 2017.