Information for Health Care Professionals

Deplin® enables antidepressants to be more effective
  • Deplin® helps synthesize new neurotransmitters and enable an antidepressant to be more effective.
  • An inadequate response to an antidepressant may be due to a lack of neurotransmitters the brain is producing.
  • Antidepressants help the brain better use the neurotransmitters available.
  • Depression is a biochemical imbalance of neurotransmitters: serotonin, norepinephrine & dopamine

Deplin® is a novel anti-depressant augmentation therapy with 7.5mg of L-methylfolate.

L-methylfolate aids in the synthesis of neurotransmitters associated with mood.

  • Deplin® tablets contain 7.5mg of L-methylfolate
  • Deplin® is the first medical food product indicated for the distinct nutritional requirements of persons with low plasma and/or low red blood cell folate with particular emphasis for those individuals who have a major depressive disorder that has not fully responded or may not fully respond to antidepressant therapy.
  • Deplin® is available by prescription only