When your patient’s current depression therapy isn’t enough... ADD THE M[]SSING PEACE
L-methylfolate is the biologically active form of folate and is involved in neurotransmitter synthesis. L-methylfolate modulates the synthesis of monoamines.

See how the active folate found in DEPLIN® is thought to help enhance production of the neurotransmitters many depressed patients need to get the most out of their antidepressant therapy.1-6

DEPLIN® Can Make a Difference When Added to an Antidepressant

DEPLIN® may provide the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively.1-3,7

The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier and is thought to help enhance the body’s natural ability to produce dopamine, norepinephrine, and serotonin.1-6


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*DEPLIN® is the only product with 15 mg of Metafolin® (L-methylfolate calcium), which is clinically proven and has been widely studied in over 25 clinical trials.

DEPLIN® is the most prescribed product in its class

DEPLIN® is the only product with 15 mg of Metafolin®* (L-methylfolate calcium), which is clinically proven and has been widely studied in over 25 clinical trials as registered on ClinicalTrials.gov.8

*Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.

See the Folate Story

See the Folate Story

Realize the role L-methylfolate plays in enhancing the
production of 3 key neurotransmitters.

References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Spector R, Lorenzo AV. Am J Physiol. 1975;229(3):777-782. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Papakostas GI, Shelton RC, Zajecka JM, et al. Am J Psychiatry. 2012;169(12):1267-1274. 6. DEPLIN [package insert]. Covington, LA: Alfasigma USA, Inc.; 2017. 7. Levitt M, Nixon PF, Pincus JH, Bertino JR. J Clin Invest. 1971;50(6):1301-1308. 8. ClinicalTrials.gov. Accessed February 1, 2016.

DEPLIN® is a prescription medical food for use only under the supervision of a physician for the clinical dietary management of depression and is specially formulated to meet the distinctive nutritional requirement for this condition. Use under medical supervision.

Manufactured and Distributed by:
Alfasigma USA, Inc.
Covington, LA 70433
© 2022 Alfasigma USA, Inc.