DEPLIN® for Healthcare Professionals
DEPLIN® Can Make a Difference When Added to an Antidepressant in Patients With Major Depressive Disorder
DEPLIN® provides the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively.1-4
The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier and is thought to help enhance the body’s natural ability to produce dopamine, norepinephrine, and serotonin.1-3,5-7
DEPLIN® is the most prescribed product in its class
DEPLIN® is the only product with 15 mg of Metafolin®*, which is branded active folate. Metafolin® is clinically proven and has been widely studied in over 25 clinical trials as registered on ClinicalTrials.gov.
*Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.
Realize the role L-methylfolate plays in enhancing the
production of 3 key neurotransmitters.
References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Spector R, Lorenzo AV. Am J Physiol. 1975;229(3):777-782. 4. Levitt M, Nixon PF, Pincus JH, Bertino JR. J Clin Invest. 1971;50(6):1301-1308. 5. Papakostas GI, Shelton RC, Zajecka JM, et al. Am J Psychiatry. 2012;169(12):1267-1274. 6. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 7. DEPLIN [package insert]. Covington, LA: Alfasigma USA, Inc.; 2017. 8. ClinicalTrials.gov. Accessed February 1, 2016.