When your patient’s current depression therapy isn’t enough... ADD THE M[]SSING PEACE
L-methylfolate is the biologically active form of folate and is involved in neurotransmitter synthesis. L-methylfolate modulates the synthesis of monoamines.

See how the active folate found in DEPLIN® is thought to help enhance production of the neurotransmitters many depressed patients need to get the most out of their antidepressant therapy.1-6

DEPLIN® Can Make a Difference When Added to an Antidepressant

DEPLIN® may provide the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively.1-3,7

The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier and is thought to help enhance the body’s natural ability to produce dopamine, norepinephrine, and serotonin.1-6


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*DEPLIN® is the only product with 15 mg of Metafolin® (L-methylfolate calcium), which is clinically proven and has been widely studied in over 25 clinical trials.

DEPLIN® is the most prescribed product in its class

DEPLIN® is the only product with 15 mg of Metafolin®* (L-methylfolate calcium), which is clinically proven and has been widely studied in over 25 clinical trials as registered on ClinicalTrials.gov.8

*Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.

See the Folate Story

See the Folate Story

Realize the role L-methylfolate plays in enhancing the
production of 3 key neurotransmitters.

References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Spector R, Lorenzo AV. Am J Physiol. 1975;229(3):777-782. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Papakostas GI, Shelton RC, Zajecka JM, et al. Am J Psychiatry. 2012;169(12):1267-1274. 6. DEPLIN [package insert]. Covington, LA: Alfasigma USA, Inc.; 2017. 7. Levitt M, Nixon PF, Pincus JH, Bertino JR. J Clin Invest. 1971;50(6):1301-1308. 8. ClinicalTrials.gov. Accessed February 1, 2016.

DEPLIN® is a medical food for use only under medical supervision for the clinical dietary management of depression and schizophrenia and is specially formulated to meet the distinctive nutritional requirement for this condition.

Manufactured and Distributed by:
Alfasigma USA, Inc.
Shreveport, LA 71104
© 2023 Alfasigma USA, Inc.


Deplin® capsules are now free from dyes.
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