DEPLIN® Can Make a Difference When Added to an Antidepressant


DEPLIN® may provide the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively. Add DEPLIN® capsules for patients who are not fully responding to their antidepressant therapy

DEPLIN® provides the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively.1-4


DEPLIN® is different from OTC folic acid*

Unlike DEPLIN®, over-the-counter (OTC) folic acid needs to be converted to its active form before it can be used in the brain, a process that may be compromised in many patients with depression.1,3-6


OTC folic acid requires multiple steps of biochemical conversion to be bioavailable1,4,7

OTC folic acid requires multiple steps of biochemical conversion to be bioavailable. OTC folic acid requires multiple steps of biochemical conversion to be bioavailable.

Copyright ©2008 Stephen M. Stahl. Reproduced with permission of Cambridge University Press.5

DHFR, dihydrofolate reductase; DHF, dihydrofolate; THF, tetrahydrofolate; MTHFD, 5,10-methylenetetrahydrofolate dehydrogenase; MTHFR, methylenetetrahydrofolate reductase.


 

See How DEPLIN® Works

See How DEPLIN® Works

The active folate found in DEPLIN®, L-methylfolate, crosses the blood-brain barrier.


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References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Levitt M, Nixon PF, Pincus JH, Bertino JR. J Clin Invest. 1971;50(6):1301-1308. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Kelly CB, McDonnell AP, Johnston TG, et al. J Psychopharmacol. 2004;18(4):567-571. 6. Gilbody S, Lewis S, Lightfoot T. Am J Epidemiol. 2007;165(1):1-13. 7. Krajinovic M. Pharmacogenomics. 2008;9(7):829-832.

DEPLIN® is a prescription medical food for use only under the supervision of a physician for the clinical dietary management of depression and is specially formulated to meet the distinctive nutritional requirement for this condition. Use under medical supervision.

Manufactured and Distributed by:
Alfasigma USA, Inc.
Covington, LA 70433
© 2018 Alfasigma USA, Inc.


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